High submodules and purity

High purity amphotericin B.

OBJECTIVES Amphotericin B (AmB) is a drug of choice for treatment of disseminated fungal infections, but its use is often associated with severe adverse effects. Our observation that generic formulations of AmB contain multiple polyene components led us to propose that removal of other polyenes would yield a high purity AmB (AmBHP) with an improved therapeutic index. METHODS To test that prem...

High Purity Distillation Column: Simulation and Optimization

Distillation columns with a high-purity product (down to 7 ppm) have been studied. A steady state model is developed using a commercial process simulator. The model is validated against industrial data. Based on the model, three major optimal operational changes are identified. These are, lowering the location of the feed & side draw streams, increasing the pressure at the top of the distillati...

Similarity Submodules and Semigroups

The similarity submodules for various lattices and modules of interest in the crystal and quasicrystal theory are determined and the corresponding semigroups, along with their zeta functions, are investigated. One application is to the colouring of crystals and quasicrystals.

Finite unions of submodules ON FINITE UNIONS OF SUBMODULES

This paper is concerned with finite unions of ideals and modules. The first main result is that if N ⊆ N1 ∪N2 ∪ · · · ∪Ns is a covering of a module N by submodules Ni, such that all but two of the Ni are intersections of strongly irreducible modules, then N ⊆ Nk for some k. The special case when N is a multiplication module is considered. The second main result generalizes earlier results on co...

robust control of a high-purity disttilation column using synthesis